Priftakis, D;
Riaz, S;
Zumla, A;
Bomanji, J;
(2020)
Towards more accurate 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging in Active and Latent Tuberculosis.
International Journal of Infectious Diseases
10.1016/j.ijid.2020.02.017.
(In press).
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Abstract
Tuberculosis is one of the leading causes of death worldwide. Although the disease is curable and preventable, it is under-diagnosed in many parts of the world. Positron emission tomography (PET) imaging using 18 F-FDG in TB can localise disease sites and extent of disease. 18F-FDG accumulates in immune cells which participate in inflammation and granuloma formation, such as activated macrophages and lymphocytes. Therefore, FDG PET/CT scanning is now being evaluated for its usefulness in diagnosis of EPTB, and monitoring response to treatment. FDG PET/CT imaging is positive and has high sensitivity in active TB, complementing conventional radiologic imaging (X-ray, CT, MRI) in the diagnosis of primary pulmonary, extrapulmonary and post-primary or miliary TB. FDG PET/CT has low specificity when it is used for solitary pulmonary nodule characterization and its ability to differentiate TB from malignancy is limited in this setting. Dual point imaging has been proposed as a way to overcome this limitation. FDG PET/CT can reliably differentiate active from inactive disease and there is promising evidence that it can contribute to response assessment to treatment with impact on patients' management. FDG PET/CT has been found positive in cases of latent TB infection and its ability for early identification of activation is being currently explored. More studies are needed to establish the method's utility in recognizing multidrug-resistant TB cases. Furthermore, other PET radiotracers might prove useful in the functional imaging of TB infection in the future.
| Type: | Article |
|---|---|
| Title: | Towards more accurate 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging in Active and Latent Tuberculosis |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2020.02.017 |
| Publisher version: | https://doi.org/10.1016/j.ijid.2020.02.017 |
| Language: | English |
| Additional information: | This an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | FDG, PET/CT, active TB, imaging, latent TB, multi-drug resistance, response assessment, tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10093260 |
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