SiO₂-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging

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SiO₂-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging

Wang, Y; Zhang, Z; Abo-zeid, Y; Bear, JC; Davies, G-L; Lei, X; Williams, GR; (2020) SiO₂-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging. Journal of Solid State Chemistry , 286 , Article 121291. 10.1016/j.jssc.2020.121291. Green open access

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Abstract

Layered gadolinium hydroxides (LGdH) have significant potential in simultaneous drug delivery and magnetic resonance imaging (MRI). In this work, we synthesized LGdH nanocomposites surface functionalised with SiO₂ nanodots (LGdH@SiO₂). We find these to have good dispersibility in cell culture medium, and a reduced tendency to aggregate compared to their uncoated analogue. Under the optimal reaction conditions, SiO₂ nanodots were evenly spread across the surface of the LGdH particles. We further intercalated ibuprofen (Ibu) and 5-fluorouracil (5FU) into LGdH@SiO₂, and explored the use of the resultant composites for drug delivery in vitro. While the SiO₂ coating could effectively reduce aggregation of the Ibu intercalate prepared by ion exchange from the parent LGdH, it was noted to increase aggregation in the case of the 5FU-loaded systems produced by coprecipitation. With a SiO₂ coating, 5FU release from the composite was almost zero-order at pH 7.4. The LGdH-5FU@SiO₂ composites can effectively inhibit the growth of A549 cells (a human adenocarcinoma cell line). In contrast, the Ibu-loaded materials are highly biocompatible. After SiO₂ modification, LGdH-5FU@SiO₂ retains the same proton relaxivity properties as LGdH-5FU, while LGdH-Ibu@SiO₂ ecomes suitable for use as a negative contrast agent in MRI. Overall, we find the LGdH@SiO₂ nanocomposites are promising materials for theranostic applications.

Type:	Article
Title:	SiO₂-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.jssc.2020.121291
Publisher version:	https://doi.org/10.1016/j.jssc.2020.121291
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Layered gadolinium hydroxides, Drug delivery, Magnetic resonance imaging, Theranostics
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI:	https://discovery.ucl.ac.uk/id/eprint/10092899