Costello, JT;
Bhogal, AS;
Williams, TB;
Bekoe, R;
Sabir, A;
Tipton, MJ;
Corbett, J;
(2020)
Effects of Normobaric Hypoxia on Oxygen Saturation Variability.
High Altitude Medicine & Biology
, 21
(1)
pp. 76-83.
10.1089/ham.2019.0092.
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Abstract
Background: The study is the first to evaluate the effects of graded normobaric hypoxia on SpO2 variability in healthy individuals. / Materials and Methods: Twelve healthy males (mean [standard deviation] age 22 [4] years) were exposed to four simulated environments (fraction of inspired oxygen [FIO2]: 0.12, 0.145, 0.17, and 0.21) for 45 minutes, in a balanced crossover design. / Results: Sample entropy, a tool that quantifies the irregularity of pulse oximetry fluctuations, was used as a measure of SpO2 variability. SpO2 entropy increased as the FIO2 decreased, and there was a strong significant negative correlation between mean SpO2 and its entropy during hypoxic exposure (r = −0.841 to −0.896, p < 0.001). In addition, SpO2 sample entropy, but not mean SpO2, was correlated (r = 0.630–0.760, p < 0.05) with dyspnea in FIO2 0.17, 0.145, and 0.12 and importantly, SpO2 sample entropy at FIO2 0.17 was correlated with dyspnea at FIO2 0.145 (r = 0.811, p < 0.01). / Conclusions: These findings suggest that SpO2 variability analysis may have the potential to be used in a clinical setting as a noninvasive measure to identify the negative sequelae of hypoxemia.
| Type: | Article |
|---|---|
| Title: | Effects of Normobaric Hypoxia on Oxygen Saturation Variability |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1089/ham.2019.0092 |
| Publisher version: | https://doi.org/10.1089/ham.2019.0092 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | SpO2 variability, dyspnea, oxygen saturation, pulse oximetry, sample entropy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092430 |
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