Boutet, A;
Gramer, R;
Steele, CJ;
Elias, GJB;
Germann, J;
Maciel, R;
Kucharczyk, W;
... Fasano, A; + view all
(2019)
Neuroimaging Technological Advancements for Targeting in Functional Neurosurgery.
Current Neurology and Neuroscience Reports
, 19
(7)
, Article 42. 10.1007/s11910-019-0961-8.
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Abstract
Purpose of Review Ablations and particularly deep brain stimulation (DBS) of a variety of CNS targets are established therapeutic tools for movement disorders. Accurate targeting of the intended structure is crucial for optimal clinical outcomes. However, most targets used in functional neurosurgery are sub-optimally visualized on routine MRI. This article reviews recent neuroimaging advancements for targeting in movement disorders. Recent Findings Dedicated MRI sequences can often visualize to some degree anatomical structures commonly targeted during DBS surgery, including at 1.5-T field strengths. Due to recent technological advancements, MR images using ultra-high magnetic field strengths and new acquisition parameters allow for markedly improved visualization of common movement disorder targets. In addition, novel neuroimaging techniques have enabled group-level analysis of DBS patients and delineation of areas associated with clinical benefits. These areas might diverge from the conventionally targeted nuclei and may instead correspond to white matter tracts or hubs of functional networks. Summary Neuroimaging advancements have enabled improved direct visualization-based targeting as well as optimization and adjustment of conventionally targeted structures.
| Type: | Article |
|---|---|
| Title: | Neuroimaging Technological Advancements for Targeting in Functional Neurosurgery |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11910-019-0961-8 |
| Publisher version: | https://doi.org/10.1007/s11910-019-0961-8 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Deep brain stimulation, Functional neurosurgery, MRI, Neuroimaging, DEEP-BRAIN-STIMULATION, SUBTHALAMIC NUCLEUS, PARKINSONS-DISEASE, 7 T, THALAMIC SEGMENTATION, DIRECTIONAL LEADS, CONNECTIVITY, VISUALIZATION, LOCALIZATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092379 |
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