Williams, B;
Brunel, P;
Lacy, PS;
Baschiera, F;
Zappe, DH;
Kario, K;
Cockcroft, J;
(2017)
Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value.
[Review].
Artery Research
, 17
(C)
pp. 1-15.
10.1016/j.artres.2016.10.154.
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Abstract
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.
| Type: | Article |
|---|---|
| Title: | Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.artres.2016.10.154 |
| Publisher version: | https://doi.org/10.1016/j.artres.2016.10.154 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Arterial stiffness, Applanation tonometry, Central aortic pressure, Clinical outcomes, Hemodynamics, Pulse waveform analysis, Wave reflection |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092312 |
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