Machado, AR;
Pereira, AC;
Ferreira, F;
Ferreira, S;
Quendera, B;
Silva, E;
Castelo-Branco, M;
(2017)
Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study.
Scientific Reports
, 7
, Article 11411. 10.1038/s41598-017-11317-7.
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Abstract
Retinitis Pigmentosa is a group of hereditary retinal dystrophy disorders associated with progressive peripheral visual field loss. The impact of this retinal loss in cortical gray matter volume has not been addressed before in Retinitis Pigmentosa patients with low vision. Voxel-based morphometry was applied to study whole brain gray matter volume changes in 27 Retinitis Pigmentosa patients with partially preserved vision and 38 age- and gender-matched normally sighted controls to determine whether peripheral visual loss can lead to changes in gray matter volume. We found significant reductions in gray matter volume that were restricted to the occipital cortex of patients. The anteromedial pattern of reduced gray matter volume in visual primary and association cortices was significantly correlated with the extent of the peripheral visual field deficit in this cohort. Moreover, this pattern was found to be associated with the extent of visual field loss. In summary, we found specific visual cortical gray matter loss in Retinitis Pigmentosa patients associated with their visual function profile. The spatial pattern of gray matter loss is consistent with disuse-driven neuronal atrophy which may have clinical implications for disease management, including prosthetic restoration strategies.
| Type: | Article |
|---|---|
| Title: | Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-017-11317-7 |
| Publisher version: | https://doi.org/10.1038/s41598-017-11317-7 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, OPEN-ANGLE GLAUCOMA, OPTICAL COHERENCE TOMOGRAPHY, RETINAL DEGENERATION, HUMAN CORTEX, BRAIN, MRI, NERVE, BLIND, 3T, THICKNESS |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092022 |
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