Minnikin, DE;
Lee, OY-C;
Wu, HHT;
Besra, GS;
Donoghue, HD;
(2020)
Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on 'Infectious diseases and Neolithic transformations' (Fuchs et al. 2019 The Holocene 29: 1545-1557).
The Holocene
10.1177/0959683619895572.
(In press).
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Abstract
The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.
Type: | Article |
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Title: | Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on 'Infectious diseases and Neolithic transformations' (Fuchs et al. 2019 The Holocene 29: 1545-1557) |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1177/0959683619895572 |
Publisher version: | https://doi.org/10.1177/0959683619895572 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Physical Sciences, Geography, Physical, Geosciences, Multidisciplinary, Physical Geography, Geology, ancient tuberculosis, DNA fragment amplification, genomes, lipid biomarkers, paleopathology, Pleistocene megafauna, tuberculosis evolution, MYCOBACTERIUM-TUBERCULOSIS, BIOMARKERS, EVOLUTION |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
URI: | https://discovery.ucl.ac.uk/id/eprint/10091998 |




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