Penna, C;
Andreadou, I;
Aragno, M;
Beauloye, C;
Bertrand, L;
Lazou, A;
Falcão-Pires, I;
... Hausenloy, DJ; + view all
(2020)
Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols.
British Journal of Pharmacology
, 177
(23)
pp. 5312-5335.
10.1111/bph.14993.
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Abstract
Diabetic patients are at increased risk of developing coronary artery disease and experience worse clinical outcomes following acute myocardial infarction (AMI). As such, novel therapeutic strategies are required to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion injury (IRI). In this regard, a number of strategies for protecting the myocardium against acute IRI have been described. These strategies include one or more brief cycles of non‐lethal ischaemia and reperfusion prior to the index ischaemic event (ischaemic preconditioning, IPC) or at the onset of reperfusion (ischaemic postconditioning, IPost) either to the heart itself or to an extracardiac organ/tissue (remote ischaemic conditioning, RIC). Experimental studies suggest that the diabetic heart is resistant to these cardioprotective strategies although clinical evidence for this are lacking. In this article, we provide an overview of the available animal models of diabetes for investigating acute myocardial IRI and cardioprotection. Next, we perform a detalied review of experimental studies investigating the effects of hyperglycaemia on susceptibility to acute myocardial IRI. We then review the response of the diabetic heart to cardioprotective strategies such as IPC, IPost and RIC. Finally, we highlight the effects of anti‐hyperglycaemic agents on susceptibility to acute myocardial IRI and cardioprotection.
| Type: | Article |
|---|---|
| Title: | Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bph.14993 |
| Publisher version: | http://dx.doi.org/10.1111/bph.14993 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Type 1 diabetes mellitus, Type 2 diabetes mellitus, animal models, anti-hyperglycaemic medications, cardioprotection, hyperglycaemia, ischaemic postconditioning, ischaemic preconditioning, remote ischaemic conditioning |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091851 |
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