Lerias, JR;
De Sousa, E;
Paraschoudi, G;
Martins, J;
Condeço, C;
Figueiredo, N;
Carvalho, C;
... Maeurer, M; + view all
(2020)
Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities.
Frontiers in Microbiology
, 10
, Article 2924. 10.3389/fmicb.2019.02924.
Preview |
Text
fmicb-10-02924.pdf - Published Version Download (1MB) | Preview |
Abstract
Memory formation, guided by microbial ligands, has been reported for innate immune cells. Epigenetic imprinting plays an important role herein, involving histone modification after pathogen-/danger-associated molecular patterns (PAMPs/DAMPs) recognition by pattern recognition receptors (PRRs). Such “trained immunity” affects not only the nominal target pathogen, yet also non-related targets that may be encountered later in life. The concept of trained innate immunity warrants further exploration in cancer and how these insights can be implemented in immunotherapeutic approaches. In this review, we discuss our current understanding of innate immune memory and we reference new findings in this field, highlighting the observations of trained immunity in monocytic and natural killer cells. We also provide a brief overview of trained immunity in non-immune cells, such as stromal cells and fibroblasts. Finally, we present possible strategies based on trained innate immunity that may help to devise host-directed immunotherapies focusing on cancer, with possible extension to infectious diseases.
| Type: | Article |
|---|---|
| Title: | Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2019.02924 |
| Publisher version: | https://doi.org/10.3389/fmicb.2019.02924 |
| Language: | English |
| Additional information: | Copyright © 2020 Lérias, de Sousa, Paraschoudi, Martins, Condeço, Figueiredo, Carvalho, Dodoo, Maia, Castillo-Martin, Beltrán, Ligeiro, Rao, Zumla and Maeurer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | trained immunity, macrophages, dendritic cells, inflammation, cancer, pathogens, immune responses, immunotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091646 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
