Baranello, G;
De Amicis, R;
Arnoldi, MT;
Zanin, R;
Mastella, C;
Masson, R;
Leone, A;
... Bertoli, S; + view all
(2020)
Evaluation of body composition as a potential biomarker in spinal muscular atrophy.
Muscle & Nerve
10.1002/mus.26823.
(In press).
Preview |
Text
Baranello_Baranello_et_al-2020-Muscle_&_Nerve.pdf - Published Version Download (742kB) | Preview |
Abstract
INTRODUCTION We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments. METHODS Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII). DISCUSSION Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII. DISCUSSION BC shows promise as a potential biomarker for SMA, but further studies are needed.
| Type: | Article |
|---|---|
| Title: | Evaluation of body composition as a potential biomarker in spinal muscular atrophy |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mus.26823 |
| Publisher version: | https://doi.org/10.1002/mus.26823 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | body composition, fat-free mass, Hammersmith Functional Motor Scale―Expanded, spinal muscular atrophy, The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091228 |
Archive Staff Only
 |
View Item |
