Deng, J;
Wang, X;
Zhang, B-Z;
Gao, P;
Lin, Q;
Kao, RY-T;
Gustafsson, K;
... Huang, J-D; + view all
(2019)
Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens.
mSphere
, 4
, Article e00362-19. 10.1128/mSphere.00362-19.
Preview |
Text
mSphere-2019-Deng-e00362-19.full.pdf - Published Version Download (2MB) | Preview |
Abstract
The demand for a prophylactic vaccine against methicillin-resistant Staphylococcus aureus (MRSA) has motivated numerous dedicated research groups to design and develop such a vaccine. In this study, we have developed a multivalent vaccine, Sta-V5, composed of five conserved antigens involved in three important virulence mechanisms. This prototype vaccine conferred up to 100% protection against multiple epidemiologically relevant S. aureus isolates in five different murine disease models. The vaccine not only elicits functional antibodies that mediate opsonophagocytic killing of S. aureus but also mounts robust antigen-specific T-cell responses. In addition, our data implied that γδ T cells contribute to the protection induced by Sta-V5 in a murine skin infection model.
| Type: | Article |
|---|---|
| Title: | Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/mSphere.00362-19 |
| Publisher version: | https://doi.org/10.1128/mSphere.00362-19 |
| Language: | English |
| Additional information: | Copyright © 2019 Deng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | γδ T cell, MRSA, multivalent vaccine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091207 |
Archive Staff Only
 |
View Item |
