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Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21

Cannavo, C; Tosh, J; Fisher, EMC; Wiseman, FK; (2020) Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21. In: Dierssen, M, (ed.) Progress in Brain Research. (pp. 181-208). Elsevier: London, UK.

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Abstract

People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer's disease and generate new clinical research questions. In addition, they suggest potential new targets for disease prevention therapies.

Type: Book chapter
Title: Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21
ISBN-13: 978-0-444-64256-1
DOI: 10.1016/bs.pbr.2019.10.004
Publisher version: https://doi.org/10.1016/bs.pbr.2019.10.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Down syndrome, Alzheimer's disease, Mouse models
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10090403
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