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Cancer Genome Evolutionary Trajectories in Metastasis

Birkbak, NJ; McGranahan, N; (2020) Cancer Genome Evolutionary Trajectories in Metastasis. Cancer Cell , 37 (1) pp. 8-19. 10.1016/j.ccell.2019.12.004. Green open access

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Abstract

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.

Type: Article
Title: Cancer Genome Evolutionary Trajectories in Metastasis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ccell.2019.12.004
Publisher version: http://dx.doi.org/10.1016/j.ccell.2019.12.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cancer drivers, cancer evolution, cancer genomics, clonal heterogeneity, evolutionary trajectories, immune escape, metastasis, metastatic drivers, monoclonal dissemination, polyclonal dissemination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10090256
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