Birkbak, NJ;
McGranahan, N;
(2020)
Cancer Genome Evolutionary Trajectories in Metastasis.
Cancer Cell
, 37
(1)
pp. 8-19.
10.1016/j.ccell.2019.12.004.
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Abstract
Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.
| Type: | Article |
|---|---|
| Title: | Cancer Genome Evolutionary Trajectories in Metastasis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ccell.2019.12.004 |
| Publisher version: | http://dx.doi.org/10.1016/j.ccell.2019.12.004 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cancer drivers, cancer evolution, cancer genomics, clonal heterogeneity, evolutionary trajectories, immune escape, metastasis, metastatic drivers, monoclonal dissemination, polyclonal dissemination |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090256 |
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