Yin, J;
Stark, RT;
Fallis, IA;
Browne, DL;
(2020)
A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions.
The Journal of Organic Chemistry
, 85
(4)
pp. 2347-2354.
10.1021/acs.joc.9b02876.
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Abstract
A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not require inert atmospheres or dry solvents, and is reported over a range of aldehyde and ketone substrates; a gram-scale process is demonstrated.
| Type: | Article |
|---|---|
| Title: | A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.joc.9b02876 |
| Publisher version: | https://doi.org/10.1021/acs.joc.9b02876 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Zinc, Lipids, Column chromatography, Chemical reactions, Ethyl groups |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090081 |
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