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The neural basis of nonword repetition in children with developmental speech or language disorder: An fMRI study

Pigdon, L; Willmott, C; Reilly, S; Conti-Ramsden, G; Liegeois, F; Connelly, A; Morgan, AT; (2020) The neural basis of nonword repetition in children with developmental speech or language disorder: An fMRI study. Neuropsychologia , 138 , Article 107312. 10.1016/j.neuropsychologia.2019.107312. Green open access

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Abstract

Developmental language disorder (DLD) and developmental speech disorder (DSD) are highly prevalent childhood conditions. An impaired ability to repeat nonsense words (“nonword repetition”), is claimed to be a robust behavioural marker for these conditions. Yet how brain function is altered during this task remains poorly understood. Previous research suggests that DLD or DSD may be associated with reduced brain activation in the inferior frontal and posterior temporal regions when compared to controls. However, this research is limited by within and between group variability in age, speech/language phenotype, and comorbidities. Here, we used functional MRI to examine brain activation during nonword repetition. As anticipated, behavioural findings confirmed that the DLD and DSD groups had poorer nonword repetition performance compared to typical controls. In contrast, fMRI revealed no statistically significant differences in brain activation, despite the groups appearing to engage slightly different regions when compared at identical thresholds. Therefore, whilst nonword repetition is a sensitive clinical marker for DLD and DSD, the findings from this study suggest that this task is not a sensitive brain MRI marker for children with these disorders, unlike for individuals with single gene mutations like FOXP2 mutations.

Type: Article
Title: The neural basis of nonword repetition in children with developmental speech or language disorder: An fMRI study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2019.107312
Publisher version: https://doi.org/10.1016/j.neuropsychologia.2019.10...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Language, Speech, fMRI, Development, Nonword repetition
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10089833
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