Muwaffak, Zaid;
(2020)
Investigation of 3D-Scanning and 3D-Printing for Personalised Therapy.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
This present thesis focuses on the combination of 3D-printing and 3D-scanning to produce personalised external and internal biomedical devices. 3D-printing enables the production of customised medical devices in regards to shape, size and drug-loading. The first chapter provides an introductory review to 3D-printing and 3D-scanning. (A formal description of the experimental results and procedures is provided in the second chapter.) The third chapter focuses on 3D-printing of external biomedical devices. Fused-deposition-modelling 3D-printing was explored to produce personalised wound dressings. 3D-Models were obtained from 3D-scanning of a volunteer’s nose, ear and hand. These dressings were 3D-printed with polycaprolactone loaded with metal-salts (copper, silver and zinc) possessing antimicrobial properties. Silver-loaded 3D-printed dressings displayed the highest antimicrobial properties, and a synergistic antimicrobial effect was produced when silver was combined with zinc. The next phase of the project focused on the development of a 3D-printed personalised positive-airway-pressure (PAP) therapy mask interface. A 3D-scanner was used to obtain a 3D-model of a volunteer’s face. The device was created using a stereolithography 3D-printer to produce a mould for the interface. This mould was filled with silicone to produce the final mask. The fourth chapter explores the use of 3D-printing to manufacture internal biomedical devices. Biocompatible and biodegradable materials were incorporated with abiraterone, docetaxel or a combination of both to produce an implant for the treatment of prostate cancer. The aim is that this implant requires surgery to implant or it could be implanted during a radical prostatectomy. The implant was 3D-printed using an Aether-bioprinter. The implant was 3D-printed with various layering systems, e.g. a drug-loaded layer followed by a drug-free layer. Analysis of the 3D-printed implant revealed that the manufacturing process did not result in any physical or chemical changes to the drugs. In addition, the drug release was controlled by changing the layer height, infill or 3D-printing with pores.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Investigation of 3D-Scanning and 3D-Printing for Personalised Therapy |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10089154 |
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