Ramachandra, C;
Kp, MMJ;
Chua, J;
Cong, S;
Shim, W;
Hausenloy, DJ;
(2020)
Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection.
Antioxidants & Redox Signaling
, 32
(15)
pp. 1135-1149.
10.1089/ars.2019.7971.
Preview |
Text
ars.2019.7971.pdf - Accepted Version Download (2MB) | Preview |
Abstract
SIGNIFICANCE: Myeloperoxidase (MPO) is a heme peroxidase that is primarily expressed by neutrophils. It has the capacity to generate several reactive species, essential for its inherent antimicrobial activity and innate host defense. Dysregulated MPO release however, can lead to tissue damage, as seen in several diseases. Increased MPO levels in circulation is therefore, widely associated with conditions of increased oxidative stress and inflammation. Recent Advances: Several studies have shown a strong correlation between MPO and cardiovascular disease (CVD), whereby elevated levels of circulating MPO are linked to poor prognosis with increased risk of CVD-related mortality. Accordingly, circulating MPO is considered a 'high-risk' biomarker for patients with acute coronary syndrome, atherosclerosis, heart failure, hypertension and stroke, thereby implicating MPO as a multifaceted target for cardiovascular protection. Consistently, recent studies that target MPO in animal models of CVD have demonstrated favorable outcomes with regard to disease progression. CRITICAL ISSUES: Although most of these studies have established a critical link between circulating MPO and worsening cardiac outcomes, the mechanisms by which MPO exerts its detrimental effects in CVD remain unclear. FUTURE DIRECTIONS: Elucidating the mechanisms by which elevated MPO leads to poor prognosis and conversely, investigating the beneficial effects of therapeutic MPO inhibition on alleviating disease phenotype, will facilitate future MPO-targeted clinical trials for improving CVD-related outcomes.
| Type: | Article |
|---|---|
| Title: | Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1089/ars.2019.7971 |
| Publisher version: | https://doi.org/10.1089/ars.2019.7971 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Myeloperoxidase; cardiovascular disease; inflammation; cardioprotection; oxidative stress; biomarker |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088817 |
Archive Staff Only
 |
View Item |
