Uijl, A;
Koudstaal, S;
Vaartjes, I;
Boer, JMA;
Verschuren, WMM;
van der Schouw, YT;
Asselbergs, FW;
... Sluijs, I; + view all
(2019)
Risk for Heart Failure The Opportunity for Prevention With the American Heart Association's Life's Simple 7.
JACC: Heart Failure
, 7
(8)
pp. 637-647.
10.1016/j.jchf.2019.03.009.
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Abstract
OBJECTIVES: The aim of this study is to determine whether combinations of specific Life’s Simple 7 (LS7) components are associated with reduced risk for heart failure (HF). BACKGROUND: The American Heart Association recommends the concept of LS7: healthy behaviors that have been shown to reduce cardiovascular disease. METHODS: A total of 37,803 participants from the EPIC-NL (European Prospective Investigation Into Cancer and Nutrition–Netherlands) cohort were included (mean age: 49.4 ± 11.9 years, 74.7% women). The LS7 score ranged from 0 to 14 and was calculated by assigning 0, 1, or 2 points for smoking, physical activity, body mass index, diet, blood pressure, total cholesterol, and blood glucose. An overall ideal score (11 to 14 points) was present in 23.2% of participants, an intermediate score (9 or 10 points) in 35.3%, and an inadequate score (0 to 8 points) in 41.5%. RESULTS: Over a median follow-up period of 15.2 years (interquartile range: 14.1 to 16.5 years), 690 participants (1.8%) developed HF. In Cox proportional hazards models, ideal and intermediate LS7 scores were associated with reduced risk for HF compared with the inadequate category (hazard ratio: 0.45 [95% confidence interval (CI): 0.34 to 0.60] and hazard ratio: 0.53 [95% CI: 0.44 to 0.64], respectively). Our analyses show that combinations with specific LS7 components, notably glucose, body mass index, smoking, and blood pressure, are associated with a lower incidence of HF. CONCLUSIONS: A healthy lifestyle, as reflected in an ideal LS7 score, was associated with a 55% lower risk for HF compared with an inadequate LS7 score. Preventive strategies that target combinations of specific LS7 components could have a significant impact on decreasing incident HF in the population at large.
| Type: | Article |
|---|---|
| Title: | Risk for Heart Failure The Opportunity for Prevention With the American Heart Association's Life's Simple 7 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jchf.2019.03.009 |
| Publisher version: | https://doi.org/10.1016/j.jchf.2019.03.009 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cardiovascular disease risk factors, healthy lifestyle, heart failure, Life's Simple 7 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088514 |
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