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The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities

Steele, CD; Pillay, N; (2020) The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities. Seminars in Cancer Biology , 61 pp. 42-55. 10.1016/j.semcancer.2019.11.009. Green open access

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Abstract

Undifferentiated sarcoma of soft tissue (USTS) are aggressive sarcomas that remain a diagnosis of exclusion and show extreme genomic complexity. Many advances in diagnostic criteria have resulted in several revisions in the definition of this rare cancer type. Recent sequencing efforts have illuminated the nature of the genome complexity and have revealed extensive copy number heterogeneity and multiple evolutionary patterns of development. This review places these recent advances into their historical and translational context and covers the changes in nomenclature, molecular classification, and the promise of personalised medicine.

Type: Article
Title: The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcancer.2019.11.009
Publisher version: https://doi.org/10.1016/j.semcancer.2019.11.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cancer, Copy number signatures, Evolution, Genomics, Sarcoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10088437
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