Garcia Redondo, PDA;
Gubert, F;
Zaverucha--Valle, C;
Pena Dutra, TP;
Ayres-Silva, ADP;
Fernandes, N;
Peixoto de Souza, AA;
... Borojevic, R; + view all
(2019)
Lymphatic vessels in human adipose tissue.
Cell and Tissue Research
10.1007/s00441-019-03108-5.
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Abstract
Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.
| Type: | Article |
|---|---|
| Title: | Lymphatic vessels in human adipose tissue |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00441-019-03108-5 |
| Publisher version: | https://doi.org/10.1007/s00441-019-03108-5 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, Lymphatics, Visceral, Subcutaneous, Adipose, Vessels, ENDOTHELIAL-CELLS, VASCULATURE, EXPRESSION, TRANSPORT, SYSTEM, FAT, ANGIOGENESIS, LIPOPROTEINS, PATHOGENESIS, OBESITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088386 |
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