Timmermann, C;
Roseman, L;
Schartner, M;
Milliere, R;
Williams, LTJ;
Erritzoe, D;
Muthukumaraswamy, S;
... Carhart-Harris, RL; + view all
(2019)
Neural correlates of the DMT experience assessed with multivariate EEG.
Scientific Reports
, 9
, Article 16324. 10.1038/s41598-019-51974-4.
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Abstract
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,NDimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) ofers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the efects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These fndings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specifc components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
| Type: | Article |
|---|---|
| Title: | Neural correlates of the DMT experience assessed with multivariate EEG |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-019-51974-4 |
| Publisher version: | https://doi.org/10.1038/s41598-019-51974-4 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10087825 |
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