Veiga, C;
Jacob, J;
Yip, N;
Szmul, A;
Landau, D;
McClelland, J;
(2019)
Objective imaging biomarkers to quantify the evolution of radiation-induced lung damage.
In:
Proceedings of the 19th International Conference on the Use of Computers in Radiation Therapy.
ICCR
(In press).
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Abstract
Radiation-induced lung damage (RILD) is a common consequence of lung cancer radiotherapy (RT). RILD is the likely cause of loss of breathing function in lung cancer survivors. RILD is traditionally described as a two-phased process according to time since RT: the acute phase (pneumonitis) occurring during the first 6 months following RT, and the permanent phase (pulmonary fibrosis) that stabilises 6 to 24 months after RT. However, in clinical practice the distinction between pneumonitis and fibrosis is often unclear. Since RILD is visible on CT imaging, its evolution can be objectively monitored and quantified. Our group has recently proposed a suite of biomarkers extracted from CT imaging to objectively quantify RILD 12-months after RT[1]. In this short paper we investigate the use of four representative imaging biomarkers to study evolution of radiological RILD up to 24 months after RT.
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