Albelda Gimeno, L;
Martin, E;
Wright, O;
Treeby, B;
(2019)
Experimental assessment of skull aberration and transmission loss at 270 kHz for focused ultrasound stimulation of the primary visual cortex.
In:
Proceedings of the 2019 IEEE International Ultrasonics Symposium (IUS).
(pp. pp. 556-559).
IEEE: Glasgow, United Kingdom, United Kingdom.
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Abstract
Transcranial focused ultrasound is a rapidly emerging method for non-invasive neuromodulation and stimulation. However, the skull causes a significant acoustic barrier and can reduce the focal intensity and alter the position and shape of the focus compared to free-field. In this study, the insertion loss and focal distortion due to the skull bone were quantified using three ex vivo human skulls and a focused ultrasound transducer operating at 270 kHz targeted on the approximate positions of the left and right primary visual cortex. Compared to free-field, the average insertion loss was -9.8 dB (± 2.2 dB), while the average focal shift was 1.7 mm (± 0.56 mm) in the lateral direction and 2.8 mm (±4.2 mm) in the axial direction. Overall, the acoustic aberrations were small compared to the size of the focal volume, meaning effective stimulation at this frequency can likely be achieved without patient-specific targeting. However, the insertion loss was significant and should be considered when selecting the target focal intensity for human studies.
| Type: | Proceedings paper |
|---|---|
| Title: | Experimental assessment of skull aberration and transmission loss at 270 kHz for focused ultrasound stimulation of the primary visual cortex |
| Event: | IEEE International Ultrasonics Symposium 2019 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/ULTSYM.2019.8926097 |
| Publisher version: | https://doi.org/10.1109/ULTSYM.2019.8926097 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Ultrasonic imaging, Acoustics, Transducers, Insertion loss, Skull, Acoustic measurements, Bones |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10087156 |
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