Edinburgh, RM;
Bradley, HE;
Abdullah, N-F;
Robinson, SL;
Chrzanowski-Smith, OJ;
Walhin, J-P;
Joanisse, S;
... Gonzalez, JT; + view all
(2020)
Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.
The Journal of Clinical Endrocrinology & Metabolism
, 105
(3)
pp. 660-676.
10.1210/clinem/dgz104.
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Abstract
CONTEXT: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. OBJECTIVE: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization, and postprandial glucose metabolism. DESIGN: 1) Acute, randomised, crossover design (Acute Study); 2) 6-week, randomised, controlled design (Training Study). SETTING: General community. PARTICIPANTS: Men with overweight/obesity (mean±SD, BMI: 30.2±3.5 kg.m-2 for Acute Study, 30.9±4.5 kg.m-2 for Training Study). INTERVENTIONS: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. RESULTS: Acute Study - exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study - postprandial glycemia was not differentially affected by 6-weeks of exercise training performed before versus after carbohydrate intake (p>0.05). However, postprandial insulinemia was reduced with exercise training performed before, but not after carbohydrate ingestion (p=0.03). This resulted in increased oral glucose insulin sensitivity (25±38 vs -21±32 mL.min-1.m-2; p=0.01), associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise before nutrient provision also augmented remodelling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (p<0.05). CONCLUSIONS: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (i.e., in the fasted state) may exert beneficial effects on lipid utilisation and reduce postprandial insulinemia.
| Type: | Article |
|---|---|
| Title: | Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1210/clinem/dgz104 |
| Publisher version: | https://doi.org/10.1210/clinem/dgz104 |
| Language: | English |
| Additional information: | Copyright © Endocrine Society 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Exercise, Glucose, Insulin sensitivity, Metabolism, Nutrition |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10085573 |
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