Ugawa, Y;
Rothwell, JC;
Paulus, W;
(2019)
Possible role of backpropagating action potentials in corticospinal neurons in I-wave periodicity following a TMS pulse.
Neuroscience Research
10.1016/j.neures.2019.10.005.
(In press).
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Abstract
A single pulse of TMS or direct electric stimulation over M1 causes repetitive synchronized firing of corticospinal tract (CST) neurons. Two mechanisms for the repetitive firing have been proposed: a cascade of synaptic inputs to the pyramidal neurons and a single reverberating circuit of interneurons. Here, we propose another possibility in which bursting of CST neurons is produced by dendritic Ca2+-spikes. Backpropagation of the initial action potential (I1-wave) from the soma interacts with synaptic input in the dendrites to initiate a dendritic calcium spike. These Ca2+-spikes produce a burst of somatic action potentials that starts about 1.5 ms after the initial discharge of the neuron, which may produce the later I-waves.
| Type: | Article |
|---|---|
| Title: | Possible role of backpropagating action potentials in corticospinal neurons in I-wave periodicity following a TMS pulse |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neures.2019.10.005 |
| Publisher version: | https://doi.org/10.1016/j.neures.2019.10.005 |
| Language: | English |
| Additional information: | © 2019 The Authors. Published by Elsevier B.V. Under a Creative Commons license (CC-BY-NC-ND) https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | TMS; Motor cortex; I wave; dendrite; Dendric computation Back; propagation activated coupling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10085170 |
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