Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis

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Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis

Rezaei Javan, R; Ramos-Sevillano, E; Akter, A; Brown, J; Brueggemann, AB; (2019) Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis. Nature Communications , 10 (1) , Article 4852. 10.1038/s41467-019-12825-y. Green open access

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Abstract

Prophages (viral genomes integrated within a host bacterial genome) can confer various phenotypic traits to their hosts, such as enhanced pathogenicity. Here we analyse >1300 genomes of 70 different Streptococcus species and identify nearly 800 prophages and satellite prophages (prophages that do not encode their own structural components but rely on the bacterial host and another helper prophage for survival). We show that prophages and satellite prophages are widely distributed among streptococci in a structured manner, and constitute two distinct entities with little effective genetic exchange between them. Cross-species transmission of prophages is not uncommon. Furthermore, a satellite prophage is associated with virulence in a mouse model of Streptococcus pneumoniae infection. Our findings highlight the potential importance of prophages in streptococcal biology and pathogenesis.

Type:	Article
Title:	Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis
Location:	England
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1038/s41467-019-12825-y
Publisher version:	https://doi.org/10.1038/s41467-019-12825-y
Language:	English
Additional information:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Bacterial genetics, Bacteriophages, Pathogens, Phage biology
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI:	https://discovery.ucl.ac.uk/id/eprint/10084641