Mansukoski, L;
Johnson, W;
Brooke-Wavell, K;
Galvez-Sobral, JA;
Furlan, L;
Cole, TJ;
Bogin, B;
(2019)
Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans.
American Journal of Human Biology
, 31
(4)
, Article e23253. 10.1002/ajhb.23253.
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Abstract
Objectives The objective of this study was to investigate the association between physical growth in preadult life with five outcomes at ages 64 to 76: weight, body mass index (BMI), estimated body fat percentage, hand grip strength, and mortality. Methods Super‐imposition by translation and rotation (SITAR) growth curves of 40 484 Guatemalan individuals aged 3 to 19 years were modeled for the parameters of size, timing and intensity (peak growth velocity, eg, cm/year) of height, weight, BMI, and grip strength. Associations between the SITAR parameters and old age outcomes were tested using linear and binary logistic regression for a follow‐up sample of high socioeconomic status (SES) Guatemalans, of whom 50 were aged 64 to 76 years at re‐measurement and 45 died prior to the year 2017. Results SITAR models explained 69% to 98% of the variance in each outcome, with height the most precise. Individuals in the follow‐up sample who had a higher BMI before the age of 20 years had higher estimated body fat (B = 1.4 CI −0.02‐2.8) and BMI (B = 1.2, CI 0.2‐2.2) at the ages of 64 to 76 years. Those who grew slower in height but faster in weight and BMI before the age of 20 years had higher BMI and body fat later in life. Conclusions These findings highlight the importance of a life course perspective on health and mortality risk. Childhood exposures leading to variation in preadult growth may be key to better understanding health and mortality risks in old age.
| Type: | Article |
|---|---|
| Title: | Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ajhb.23253 |
| Publisher version: | https://doi.org/10.1002/ajhb.23253 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Anthropology, Biology, Life Sciences & Biomedicine - Other Topics, CARDIOMETABOLIC RISK, SKELETAL MATURATION, CHILDHOOD OBESITY, SCHOOL-CHILDREN, ADULT OBESITY, GROWTH, BIRTH, AGE, ADOLESCENCE, PREDICTOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081903 |
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