Sudakou, A;
Lange, F;
Isler, H;
Gerega, A;
Ostojic, D;
Sawosz, P;
Tachtsidis, I;
... Liebert, A; + view all
(2019)
Multi-wavelength time-resolved NIRS measurements for estimation of absolute concentration of chromophores: blood phantom study.
In:
Diffuse Optical Spectroscopy and Imaging VII.
SPIE: Munich, Germany.
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Sudakou et al. - 2019 - Multi-wavelength time-resolved NIRS measurements for estimation of absolute concentration of chromophores blood.pdf - Published Version Download (424kB) | Preview |
Abstract
Absolute concentrations of oxyhaemoglobin and deoxyhaemoglobin obtained using multi-wavelength measurements of time-resolved diffuse reflectance signals are presented. The aim was to test how accurately the concentration of oxy- and deoxyhemoglobin can be measured simultaneously at multiple wavelengths. The optical signals were collected using the system constructed by the author’s group a , which records the distribution in time of flight of photons (DTOFs) simultaneously at 16 spectral channels ranging from 650 to 850 nm. The measurements were carried out on liquid phantoms containing intralipid solution, human blood and yeast in varying amounts. The oxygen saturation of blood covered a continuous range from 100 % to 0 % during 6 deoxygenation cycles. The estimated values of total haemoglobin (20.9, 35.7, 57.3, 45.7 μM) are close to the reference values obtained using a blood gas analyzer (21.3, 37.0, 57.3, 48.0 μM) and the estimated values of absolute concentrations of oxy-, deoxyand total haemoglobin are similar to the values obtained using a commercial frequency-domain NIRS system (OxiplexTS TM). The phantom measurements have shown the capability to measure the absolute concentrations of chromophores in a studied media using multi-wavelength, time-resolved NIRS technique. The excess number of spectral channels can potentially be used to resolve changes in oxidation state of cytochrome-c-oxidase enzyme.
| Type: | Proceedings paper |
|---|---|
| Title: | Multi-wavelength time-resolved NIRS measurements for estimation of absolute concentration of chromophores: blood phantom study |
| Event: | European Conferences on Biomedical Optics |
| Dates: | 23 June 2019 - 27 June 2019 |
| ISBN-13: | 9781510628410 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2527215 |
| Publisher version: | https://doi.org/10.1117/12.2527215 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | diffuse optics, time-resolved NIRS, blood phantom, oxygen saturation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081768 |
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