Yang, Ye;
(2019)
On the Interplay of Gold Nanoparticles and Small Molecules.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Gold nanoparticles (AuNPs) have been widely used in optical, catalytic, chemical and biomedical applications due to their distinct physicochemical properties. Molecular recognition and the binding of chemical and biological entities have attracted particular research interest for the relevance in drug delivery and diagnostics. By addressing material design as well as advanced characterisation methods, this thesis aims to shed light on fundamental aspects of AuNPs, including the synthesis, functionalisation and implications for relevant applications. A versatile AuNP synthesis enabled the decoupling of core size refinement and ligand shell variation in sub-10 nm thiol-capped AuNPs, thus providing a novel solution of comparative fine-tuning of the ligand shell composition. The analysis of AuNP size distribution was addressed with a comparative study employing single particle analysis (electron microscopy imaging) and ensemble methods (X-ray scattering and analytical ultracentrifugation). Subsequently, nanoscale colloidal stability and molecular interaction with small molecules were investigated both in solution by small-angle X-ray scattering and on a surface by quartz crystal microbalance with dissipation monitoring. This work establishes a versatile platform for AuNP engineering with target size and surface functionality and provides a powerful toolbox for systematic studies on colloidal behaviour as well as ligand-shell mediated nanoparticle-stimuli interactions for biomedical applications.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | On the Interplay of Gold Nanoparticles and Small Molecules |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2019. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| Keywords: | gold nanoparticle, molecular interaction, colloidal stability, SAXS, QCM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081717 |
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