Schonmann, Y;
Mansfield, KE;
Hayes, JF;
Abuabara, K;
Roberts, A;
Smeeth, L;
Langan, SM;
(2020)
Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study.
Journal of Allergy and Clinical Immunology: In Practice
, 8
(1)
248-257.e16.
10.1016/j.jaip.2019.08.030.
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Abstract
BACKGROUND: Atopic eczema is a common and debilitating condition associated with depression and anxiety, but the nature of this association remains unclear. // OBJECTIVE: To explore the temporal relationship between atopic eczema and new depression/anxiety. // METHODS: A matched cohort study using routinely-collected data from the UK Clinical Practice Research Datalink, linked to hospital admissions data. We identified adults with atopic eczema (1998-2016) using a validated algorithm, and up to five individuals without atopic eczema matched on date of diagnosis, age, sex and general practice. We estimated the hazard ratio (HR) for new depression/anxiety using stratified Cox regression to account for age, sex, calendar period, Index of Multiple Deprivation, glucocorticoid treatment, obesity, smoking and harmful alcohol use. // RESULTS: We identified 526,808 adults with atopic eczema who were matched to 2,569,030 without. Atopic eczema was associated with increased incidence of new depression (HR 1.14; 99% confidence interval [CI] 1.12-1.16), and anxiety (HR 1.17; 99% CI 1.14-1.19). We observed a stronger effect of atopic eczema on depression with increasing atopic eczema severity (HR [99% CI] compared to no atopic eczema: mild 1.10 [1.08-1.13]; moderate 1.19 [1.15-1.23]; severe 1.26 [1.17-1.37]). A dose-response association, however, was less apparent for new anxiety diagnosis (HR [99% CI] compared to no atopic eczema: mild 1.14 [1.11-1.18]; moderate 1.21 [1.17-1.26]; severe 1.15; [1.05-1.25]). // CONCLUSIONS: Adults with atopic eczema are more likely to develop new depression and anxiety. For depression, we observed a dose-response relationship with atopic eczema severity.
| Type: | Article |
|---|---|
| Title: | Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jaip.2019.08.030 |
| Publisher version: | https://doi.org/10.1016/j.jaip.2019.08.030 |
| Language: | English |
| Additional information: | © 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://doi.org/10.1016/j.jaip.2019.08.030 |
| Keywords: | Anxiety, atopic dermatitis, atopic eczema, depression, population-based, severity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081518 |
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