Kiernan, MC;
Bostock, H;
Park, SB;
Kaji, R;
Krarup, C;
Krishnan, AV;
Kuwabara, S;
... Burke, D; + view all
(2019)
Measurement of axonal excitability: Consensus guidelines.
Clinical Neurophysiology
10.1016/j.clinph.2019.07.023.
(In press).
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Abstract
Measurement of axonal excitability provides an in vivo indication of the properties of the nerve membrane and of the ion channels expressed on these axons. Axonal excitability techniques have been utilised to investigate the pathophysiological mechanisms underlying neurological diseases. This document presents guidelines derived for such studies, based on a consensus of international experts, and highlights the potential difficulties when interpreting abnormalities in diseased axons. The present manuscript provides a state-of-the-art review of the findings of axonal excitability studies and their interpretation, in addition to suggesting guidelines for the optimal performance of excitability studies.
| Type: | Article |
|---|---|
| Title: | Measurement of axonal excitability: Consensus guidelines |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clinph.2019.07.023 |
| Publisher version: | https://doi.org/10.1016/j.clinph.2019.07.023 |
| Language: | English |
| Additional information: | © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Axon, Excitability, Guidelines, Peripheral nerve, Threshold |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081276 |
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