Timmons, JA;
Gallagher, IJ;
Sood, S;
Phillips, B;
Crossland, H;
Howard, R;
Kraus, WE;
(2019)
A statistical and biological response to an informatics appraisal of healthy aging gene signatures.
[Letter].
Genome Biology
, 20
, Article 152. 10.1186/s13059-019-1734-z.
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Abstract
Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.
| Type: | Article |
|---|---|
| Title: | A statistical and biological response to an informatics appraisal of healthy aging gene signatures |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13059-019-1734-z |
| Publisher version: | https://doi.org/10.1186/s13059-019-1734-z |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081257 |
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