Panagiotopoulou, O;
Chiesa, S;
Tousoulis, D;
Charakida, M;
(2020)
Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors.
Current Medicinal Chemistry
, 27
(27)
pp. 4494-4521.
10.2174/0929867326666190827151012.
Preview |
Text
Chiesa_AAM_PCSK9 review.pdf - Accepted Version Download (762kB) | Preview |
Abstract
Genetic, experimental and clinical studies have consistently confirmed that inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) can result in significant LDL-C lowering and two fully human PCSK9 mononclonal antibodies have received regulatory approval for use in high-risk patients. Co- administration of PCSK9 with statins has resulted in extremely low LDL-C levels with excellent short-term safety profiles. While results from Phase III clinical trials provided exciting evidence about the role of PCSK9 inhibitors in reducing cardiovascular event rates, their impact on mortality remains less clear. PCSK9 inhibitor therapy can be considered for high risk patients who are likely to experience the largest cardiovascular risk reduction benefit.
| Type: | Article |
|---|---|
| Title: | Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2174/0929867326666190827151012 |
| Publisher version: | https://doi.org/10.2174/0929867326666190827151012 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | PCSK9, Proprotein Convertase Subtilisin/Kexin type 9, Alirocumab, Evolocumab, LDL-cholesterol, monoclonal antibodies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10080988 |
Archive Staff Only
 |
View Item |
