Johansson, V;
Erhardt, S;
Engberg, G;
Kegel, M;
Bhat, M;
Schwieler, L;
Blennow, K;
... Landén, M; + view all
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
European Archives of Psychiatry and Clinical Neuroscience
10.1007/s00406-019-01042-9.
(In press).
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Abstract
Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fuid of 23 twins afected from schizophrenia, bipolar disorder or unafected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental infuences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed.
| Type: | Article |
|---|---|
| Title: | Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00406-019-01042-9 |
| Publisher version: | https://doi.org/10.1007/s00406-019-01042-9 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Twin study · Cerebrospinal fuid · Biomarker · Kynurenic acid · Monocyte chemoattractant protein-1 · Chemokine ligand 2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10079249 |
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