Haan, JD;
van de Kreeke, JA;
Konijnenberg, E;
Kate, MT;
Braber, AD;
Barkhof, F;
van Berckel, BN;
... Bouwman, FH; + view all
(2019)
Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 11
pp. 463-471.
10.1016/j.dadm.2019.05.002.
(In press).
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Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimers disease.pdf - Published Version Download (798kB) | Preview |
Abstract
Introduction: Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer’s disease (AD). We therefore measured retinal thickness in well-characterized AD and control participants, considering ophthalmological confounders. Methods: We included 57 amyloid-proven AD cases and 85 cognitively normal, amyloid-negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease. Results: Retinal thickness did not discriminate cases from controls, including stratified analyses for early- versus late-onset AD. We found significant associations between macular thickness and global cortical atrophy [b 20.358; P 5 .01] and parietal cortical atrophy on magnetic resonance imaging [b 20.371; P , .01] in AD cases. Discussion: In this study, representing the largest optical coherence tomography cohort with amyloid-proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker
| Type: | Article |
|---|---|
| Title: | Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.dadm.2019.05.002 |
| Publisher version: | https://doi.org/10.1016/j.dadm.2019.05.002 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Retinal thickness; Cortical atrophy; Alzheimer’s disease; Neurodegeneration; Biomarker |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10079111 |
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