Swainson, SME;
Taresco, V;
Pearce, AK;
Clapp, LH;
Ager, B;
McAllister, M;
Bosquillon, C;
(2019)
Exploring the enzymatic degradation of poly(glycerol adipate).
European Journal of Pharmaceutics and Biopharmaceutics
, 142
pp. 377-386.
10.1016/j.ejpb.2019.07.015.
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Abstract
Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in self-assembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer’s potential as a drug delivery platform.
| Type: | Article |
|---|---|
| Title: | Exploring the enzymatic degradation of poly(glycerol adipate) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ejpb.2019.07.015 |
| Publisher version: | https://doi.org/10.1016/j.ejpb.2019.07.015 |
| Language: | English |
| Additional information: | © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Poly(glycerol adipate), Enzymatic degradation, Polyester, Biodegradable, Polymer modification, Breakdown |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078950 |
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