Vilares, I;
Nolte, T;
Hula, A;
Cui, Z;
Fonagy, P;
Zhu, L;
Chiu, P;
... Montague, R; + view all
(2019)
Computational Phenotyping in Borderline Personality Using a Role-Based Social Hierarchy Probe.
Presented at: 74th Annual Meeting of the Society-of-Biological-Psychiatry (SOBP), Chicago, IL, USA.
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Abstract
Background Dysfunction in social interactions is a hallmark of several psychiatric disorders. There has thus been a substantial recent interest in characterizing aberrant and normal social decision-making using games from experimental economics. However, these studies have so far covered only a small range of social interactions. One important omission has been social dominance. A maladaptive reaction to social dominance may be particularly relevant for neuropsychiatric disorders such as borderline personality disorder (BPD) in which there is trouble sustaining social relations. Here, we examined how people with BPD behave in social interactions involving differences in social dominance. Methods Participants (169 controls and 313 BPDs) played a multi-round Social Hierarchy game where money could be used to increase (or maintain) social status. We then fit computational models to the recorded behavior. Results We found no difference between patients with BPD and Controls in the amount spent to become or stay dominant, the challenge rate, or the number of rounds in the dominant position (p>0.05). However, and contrary to expectations, we found that BPDs in the dominant position offered higher initial transfers to the other player compared to controls (p=0.03). In the computational model, this was associated with a higher positive inequity aversion parameter. Furthermore, BPD patients challenged more when given an unfair transfer (p=0.02). Conclusions Our results suggest that BPD patients and Controls value social dominance similarly but that BPD patients may be more inequity averse. We offer specific computational parameters that can be used to quantitatively characterize and phenotype each individual.
| Type: | Conference item (Presentation) |
|---|---|
| Title: | Computational Phenotyping in Borderline Personality Using a Role-Based Social Hierarchy Probe |
| Event: | 74th Annual Meeting of the Society-of-Biological-Psychiatry (SOBP) |
| Location: | Chicago, IL, USA |
| Dates: | 16 May 2019 - 18 May 2019 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biopsych.2019.03.273 |
| Publisher version: | https://doi.org/10.1016/j.biopsych.2019.03.273 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Computational Psychiatry, Borderline Personality Disorder, Neuroeconomics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078531 |
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