Shelmerdine, SC;
Hutchinson, JC;
Ward, L;
Sekar, T;
Ashworth, MT;
Levine, S;
Sebire, NJ;
(2020)
INTACT (INcision‐less TArgeted Core Tissue) biopsy procedure for perinatal autopsy: initial feasibility.
Ultrasound in Obstetrics & Gynecology
, 55
(5)
pp. 667-675.
10.1002/uog.20387.
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Abstract
OBJECTIVES: To determine the feasibility and tissue yield from a perinatal incision-less ultrasound guided biopsy procedure, in the context of a 'minimally invasive autopsy' (MIA). METHODS: Perinatal cases that consented for MIA underwent post-mortem MRI and 'INcisionless TArgeted Core Tissue' (INTACT) biopsy procedure, defined as organ needle biopsy via the umbilical cord performed under ultrasound guidance. Three cores of tissue were obtained from 7 target organs for each case (both lungs, both kidneys, heart, spleen and liver). Biopsy success rate was pre-defined as an adequate volume of the intended target organ for pathological analysis, judged by a pathologist blinded to the case and biopsy procedure. RESULTS: Thirty fetuses underwent organ sampling. The mean gestational age was 30 weeks (18-40 weeks) and mean delivery to biopsy time was 12 days (6-22 days). The overall success rate was 153/201 samples (76.1%), with success rates of individual organs highest for heart and lungs (93%, 92% respectively) and lowest for spleen (11%). Excluding splenic samples, the biopsy success rate would have been 150/173 (86.7%). Histological abnormalities were found in 4/201 (2%) samples - in the lungs and kidneys of a fetus with pulmonary hypoplasia and multicystic kidney disease. CONCLUSIONS: Incision-less ultrasound guided organ biopsies are feasible, with overall success rates of >75%. This novel INTACT technique offers the ideal combination of an imaging-led autopsy with organ sampling for parents who decline the conventional invasive approach. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | INTACT (INcision‐less TArgeted Core Tissue) biopsy procedure for perinatal autopsy: initial feasibility |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/uog.20387 |
| Publisher version: | https://doi.org/10.1002/uog.20387 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Autopsy, minimally invasive autopsy, paediatric, perinatal, ultrasound |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078169 |
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