Papazoglou, S;
Streubel, T;
Ashtarayeh, M;
Pine, KJ;
Edwards, LJ;
Brammerloh, M;
Kirilina, E;
... Mohammadi, S; + view all
(2019)
Biophysically motivated efficient estimation of the spatially isotropic R*₂ component from a single gradient‐recalled echo measurement.
Magnetic Resonance in Medicine
10.1002/mrm.27863.
(In press).
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Abstract
PURPOSE: To propose and validate an efficient method, based on a biophysically motivated signal model, for removing the orientation‐dependent part of R*₂ using a single gradient‐recalled echo (GRE) measurement. METHODS: The proposed method utilized a temporal second‐order approximation of the hollow‐cylinder‐fiber model, in which the parameter describing the linear signal decay corresponded to the orientation‐independent part of R*₂. The estimated parameters were compared to the classical, mono‐exponential decay model for R*₂ in a sample of an ex vivo human optic chiasm (OC). The OC was measured at 16 distinct orientations relative to the external magnetic field using GRE at 7T. To show that the proposed signal model can remove the orientation dependence of R*₂, it was compared to the established phenomenological method for separating R*₂ into orientation‐dependent and ‐independent parts.
| Type: | Article |
|---|---|
| Title: | Biophysically motivated efficient estimation of the spatially isotropic R*₂ component from a single gradient‐recalled echo measurement |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.27863 |
| Publisher version: | https://doi.org/10.1002/mrm.27863 |
| Language: | English |
| Additional information: | © 2019 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | R*₂, anisotropy, apparent transverse relaxation rate, biophysical signal model, gradient-recalled echo, orientation dependence, white matter |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078073 |
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