Weis, J;
Wirtz, MA;
Tomaszewski, KA;
Hammerlid, E;
Arraras, JI;
Conroy, T;
Lanceley, A;
... EORTC Quality of Life Group; + view all
(2019)
Sensitivity to change of the EORTC quality of life module measuring cancer related fatigue (EORTC QlQ-Fa12): results from the international psychometric validation.
Psycho-Oncology
, 28
(8)
pp. 1753-1761.
10.1002/pon.5151.
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Lanceley EORTC FA 12 Sensitivity manuscript PON_FINAL12-05-19_.pdf - Accepted Version Download (491kB) | Preview |
Abstract
OBJECTIVE: The European Organisation for Research and Treatment of Cancer Quality of Life Group (EORTC QLG) has developed a multidimensional instrument measuring cancer related fatigue, the EORTC QLQ-FA12. The analysis of sensitivity to change is an essential part of psychometric validation. With this study, we investigated the EORTC QLQ-FA12's sensitivity to change. METHODS: The methodology follows the EORTC guidelines of EORTC QLG for phase IV validation of modules. We included cancer patients undergoing curative and palliative treatment at t1 and followed them up prospectively over the course of their treatment (t2) and four weeks after completion of treatment (t3). Data were collected prospectively at 17 sites in eleven countries. Sensitivity to change was investigated using analysis of variance (ANOVA). RESULTS: A total sample of 533 patients was enrolled with various tumour types, different stages of cancer, and receiving either curative treatment (n=311) or palliative treatment (n=222). Over time all fatigue scores were significantly higher in the palliative treatment group compared with the curative group (p < .001). Physical fatigue increased with medium effect size over the course of treatment in the curative group [SRM(t1,t2) = 0.44]. After treatment physical [SRM(t2,t3) = 0.39], emotional [SRM(t2,t3)= 0.28] and cognitive fatigue [SRM(t2,t3) = 0.22] declined significantly in the curative group. In the palliative group emotional [SRM(t2,t3) = 0.18] as well as cognitive [SRM(t2,t3) = 0.26] fatigue increases significantly. CONCLUSIONS: The EORTC-QLQ-FA12 proved to identify clinically significant changes in fatigue in the course of curative and palliative cancer treatment.
| Type: | Article |
|---|---|
| Title: | Sensitivity to change of the EORTC quality of life module measuring cancer related fatigue (EORTC QlQ-Fa12): results from the international psychometric validation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/pon.5151 |
| Publisher version: | https://doi.org/10.1002/pon.5151 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cancer related fatigue, EORTC quality of life group, international field validation, module development, quality of life, sensitivity to change |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10077436 |
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