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Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload

Singh, V; Guo, T; Wu, L; Xu, J; Liu, B; Gref, R; Zhang, J; (2017) Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload. RSC Advances , 7 (34) pp. 20789-20794. 10.1039/C7RA02306E. (In press). Green open access

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Abstract

Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized γ-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2–4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges.

Type: Article
Title: Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C7RA02306E
Publisher version: http://dx.doi.org/10.1039/C7RA02306E
Language: English
Additional information: © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10075870
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