Singh, V;
Guo, T;
Wu, L;
Xu, J;
Liu, B;
Gref, R;
Zhang, J;
(2017)
Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload.
RSC Advances
, 7
(34)
pp. 20789-20794.
10.1039/C7RA02306E.
(In press).
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Abstract
Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized γ-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2–4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges.
| Type: | Article |
|---|---|
| Title: | Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/C7RA02306E |
| Publisher version: | http://dx.doi.org/10.1039/C7RA02306E |
| Language: | English |
| Additional information: | © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10075870 |
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