Vaidya, JS;
Jain, A;
Diniz, RS;
(1986)
Anti-inflammatory activity of furosemide and spironolactone.
Clinician
, 50
(11)
pp. 380-384.
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Abstract
Two diuretics - furosemide and spironolactone - were investigated for anti-inflammatory activity in two models of inflammation, namely, exudative phase (carrageenin-induced rat hind paw oedema) and proliferative phase (cotton pellet-induced granuloma in mice). Phe-nylbutazone, a non steroidal anti-inf lam-mator agent was used as a standard drug for comparison. In both the models of inflammation, furosemide showed statistically significant anti-inflammatory activity. Spironolactone, however, failed to exhibit significant anti-inflammatory activity in the model for acute inflammation though it was very effective in chronic inflammation.
| Type: | Article |
|---|---|
| Title: | Anti-inflammatory activity of furosemide and spironolactone |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10075119 |
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