Merisson, E;
Mattsson, N;
Zetterberg, H;
Blennow, K;
Pikwer, A;
Mehmedagic, I;
Acosta, S;
(2016)
Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair.
Neurochemistry International
, 93
pp. 1-5.
10.1016/j.neuint.2015.12.003.
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Abstract
Background Repair of extensive aortic disease may be associated with spinal cord ischaemia (SCI). Here we test if levels of cerebrospinal fluid (CSF) biomarkers for neuronal injury are altered in patients with SCI after advanced endovascular repair in extensive aortic disease. Methods CSF was sampled for up to 48 h in ten patients undergoing endovascular aortic repair and analyzed for the axonal damage markers total-tau (T-tau) and neurofilament light (NFL). Results Six of ten patients developed SCI (clinically present within 3–6 h). CSF levels of NFL increased up to 37-fold in patients with, but were stable in patients without, SCI. CSF levels of T-tau also increased in patients with SCI, but with some overlap with patients without SCI. Levels of NFL and T-tau did not increase until after the appearance of clinical signs of neurological dysfunction (12–48 h after aortic repair). Conclusions The CSF biomarkers NFL and T-tau both reflect development of SCI after endovascular aortic repair, but do not rise until after clinical signs of SCI appear. Future studies are desirable to further evaluate potential use of these biomarkers for assessment of the severity of SCI, and also to identify earlier biomarkers of SCI.
| Type: | Article |
|---|---|
| Title: | Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuint.2015.12.003 |
| Publisher version: | https://doi.org/10.1016/j.neuint.2015.12.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Neurosciences, Neurosciences & Neurology, Aortic disease, Biomarker, Cerebrospinal fluid, Endovascular, NFL, Tau, CEREBROSPINAL-FLUID, BIOMARKERS, ANEURYSM, SURGERY, RISK, PARAPLEGIA, DISEASE, INJURY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074813 |
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