UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Catatonia and the immune system: a review

Rogers, JP; Pollak, TA; Blackman, G; David, A; (2019) Catatonia and the immune system: a review. The Lancet Psychiatry , 6 (7) pp. 620-630. 10.1016/S2215-0366(19)30190-7. Green open access

[thumbnail of David_Catatonia and immune dysregulationfinal Word version Lancet Psychiatry.pdf]
Preview
Text
David_Catatonia and immune dysregulationfinal Word version Lancet Psychiatry.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Catatonia is a psychomotor disorder featuring stupor, posturing, and echophenomena. This Series paper examines the evidence for immune dysregulation in catatonia. Activation of the innate immune system is associated with mutism, withdrawal, and psychomotor retardation, which constitute the neurovegetative features of catatonia. Evidence is sparse and conflicting for acute-phase activation in catatonia, and whether this feature is secondary to immobility is unclear. Various viral, bacterial, and parasitic infections have been associated with catatonia, but it is primarily linked to CNS infections. The most common cause of autoimmune catatonia is N-methyl-D-aspartate receptor (NMDAR) encephalitis, which can account for the full spectrum of catatonic features. Autoimmunity appears to cause catatonia less by systemic inflammation than by the downstream effects of specific actions on extracellular antigens. The specific association with NMDAR encephalitis supports a hypothesis of glutamatergic hypofunction in catatonia.

Type: Article
Title: Catatonia and the immune system: a review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2215-0366(19)30190-7
Publisher version: https://doi.org/10.1016/S2215-0366(19)30190-7
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10074761
Downloads since deposit
839Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item