Palombo, M;
Ligneul, C;
Valette, J;
(2017)
Modeling diffusion of intracellular metabolites in the mouse brain up to very high diffusion-weighting: Diffusion in long fibers (almost) accounts for non-monoexponential attenuation.
Magnetic Resonance in Medicine
, 77
(1)
pp. 343-350.
10.1002/mrm.26548.
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Abstract
Purpose: To investigate how intracellular metabolites diffusion measured in vivo up to very high q/b in the mouse brain can be explained in terms of simple geometries. / Methods: 10 mice were scanned using our new STE‐LASER sequence, at 11.7 Tesla (T), up to qmax = 1 μm−1 at diffusion time td = 63.2 ms, corresponding to bmax = 60 ms/µm². We model cell fibers as randomly oriented cylinders, with radius a and intracellular diffusivity urn:x-wiley:07403194:media:mrm26548:mrm26548-math-0004, and fit experimental data as a function of q to estimate urn:x-wiley:07403194:media:mrm26548:mrm26548-math-0005 and a. / Results: Randomly oriented cylinders account well for measured attenuation, giving fiber radii and urn:x-wiley:07403194:media:mrm26548:mrm26548-math-0006 in the expected ranges (0.5–1.5 µm and 0.30–0.45 µm2/ms, respectively). The only exception is N‐acetyl‐aspartate (NAA) (extracted a∼0), which we show to be compatible with a small fraction of the NAA pool being confined in highly restricted compartments (with short T2). / Conclusion: The non‐monoexponential signal attenuation of intracellular metabolites in the mouse brain can be described by diffusion in long and thin cylinders, yielding realistic Dintra and fiber diameters. However, this simple model may require small “corrections” for NAA, in the form of a small fraction of the NAA signal originating from a highly restricted compartment.
| Type: | Article |
|---|---|
| Title: | Modeling diffusion of intracellular metabolites in the mouse brain up to very high diffusion-weighting: Diffusion in long fibers (almost) accounts for non-monoexponential attenuation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.26548 |
| Publisher version: | https://doi.org/10.1002/mrm.26548 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | metabolites diffusion, diffusion‐weighted MRS, geometrical model, cell morphology, cell geometry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074397 |
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