An, Z;
Sabalic, M;
Bloomquist, RF;
Fowler, TE;
Streelman, T;
Sharpe, PT;
(2018)
A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors.
Nature Communications
, 9
, Article 378. 10.1038/s41467-017-02785-6.
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A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors.pdf - Published Version Download (8MB) | Preview |
Abstract
The extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1+ MSCs decrease dramatically in number. When adult incisors are cut, the growth rate increases to rapidly re-establish tooth length and homeostasis. This accelerated growth rate correlates with the re-appearance of CD90/Thy+ MSCs and re-establishment of their contribution to cell differentiation. A population of Celsr1+ quiescent cells becomes mitotic following clipping and replenishes the CD90/Thy1 population. A sub-population of MSCs thus exists in the mouse incisor, distinguished by expression of CD90/Thy1 that plays a specific role only during periods of increased growth rate
| Type: | Article |
|---|---|
| Title: | A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-017-02785-6 |
| Publisher version: | https://doi.org/10.1038/s41467-017-02785-6 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10072994 |
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