Garcia-Sampedro, A;
Tabero, A;
Mahamed, I;
Acedo, P;
(2019)
Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications.
Journal of Porphyrins and Phthalocyanines
, 23
(1-2)
pp. 11-27.
10.1142/S1088424619500111.
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Abstract
The cationic porphyrin meso-tetra(4-N-methylpyridyl)porphine (TMPyP) has a high yield of singlet oxygen generation upon light activation and a strong affinity for DNA. These advantageous properties have turned it into a promising photosensitizer for use in photodynamic therapy (PDT). In this review, we have summarized the current state-of-the-art applications of TMPyP for the treatment of cancer as well as its implementation in antimicrobial PDT. The most relevant studies reporting its pharmacokinetics, subcellular localization, mechanism of action, tissue biodistribution and dosimetry are discussed. Combination strategies using TMPyP-PDT together with other photosensitizers and chemotherapeutic agents to achieve synergistic anti-tumor effects and reduce resistance to therapy are also explored. Finally, we have addressed emerging applications of this porphyrin, including nanoparticle-mediated delivery, controlled drug release, biosensing and G-quadruplex stabilization for tumor growth inhibition. Altogether, this work highlights the great potential and versatility that TMPyP can offer in different fields of biomedicine such us cancer treatment or antimicrobial therapy.
| Type: | Article |
|---|---|
| Title: | Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1142/S1088424619500111 |
| Publisher version: | http://doi.org/10.1142/S1088424619500111 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | porphyrins, photodynamic therapy, antimicrobial inactivation, reactive oxygen species, combination therapy, nanoparticles |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10072128 |
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