Idiris, FIM;
Jones, CR;
(2017)
Recent advances in fluoride-free aryne generation from arene precursors.
[Review].
Organic and Biomolecular Chemistry
, 15
(43)
pp. 9044-9056.
10.1039/c7ob01947e.
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Abstract
Aryne chemistry has experienced a remarkable renaissance in recent years, with a significant increase in the synthetic applications reported for these highly valuable reactive intermediates. This resurgence of interest is in part due to the introduction of ortho-silylaryl triflates as precursors which can be activated under mild conditions using fluoride. Alternative fluoride-free strategies have received interest in the last decade, with a number of precursors to arynes and their activators reported. These approaches offer alternative modes of reactivity which prove, in some cases, to be orthogonal to those of ortho-silylaryl triflates. This review highlights some of the more recent fluoride-free methodologies developed to access aryne intermediates that start from arene-based precursors.
| Type: | Article |
|---|---|
| Title: | Recent advances in fluoride-free aryne generation from arene precursors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c7ob01947e |
| Publisher version: | http://doi.org/10.1039/c7ob01947e |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10070986 |
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